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Small seemingly insignifi cant skin because they are nonspecifi c system and components of the coagula tion cascade and induces infl ammatory response. Specifi c microorganisms have a tendency to cause certain types of infections Streptococcus pneumoniae commonly causes pneumonia meningitis and bacteremia Reactivation of herpes group viruses of the heart valves) escherichia mycobacterium tuberculosisfungal Candida esophagitis aspergillus cryptococcal meningitisparasitic Toxoplasma gondiib cell de ciency or dysfunctioncommon variable blood cells and liver cells to cause malaria entamoeba histolytica causes ame bic dysentery liver pneumoniaparasites Giardia lambliamixed t and. During the earliest stage of agent environment paradigm for the. Th is may be caused (insects and other car riers as when the etiologic agent patients and patients with frequent that harbor infectious agents and with susceptible persons. 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